Manager Joe Girardi gave Granderson the day off for a combination of reasons -- including that Granderson had played back-to-back days with his rehab assignment, that it was a day game after a night game and that the Yankees are facing left-hander David Huff.
Girardi said he might give Granderson another day off next weekend in Toronto, after which "he'll be full go."
Granderson himself said Friday night that the injury wasn't much of a concern.
"The actual injury doesn't bother me. It's just the rest of my body," Granderson said, adding that the feeling was similar to the start of Spring Training. "It's going to be a lot of work just to get back in the groove of things."
Granderson went 1-for-3 in his return with a double and a run scored. Kevin Russo got the start in left field with Brett Gardner sliding over to center.