Jeter had been hit by a pitch in the back of his left thigh in the second inning by Cleveland's Mitch Talbot. He stayed in the game then and recorded a pair of singles in his next two at-bats. After the second of those hits -- a one-out single in the seventh -- Ramiro Pena came on to pinch-run for Jeter.
"He got hit in the back of the hamstring and it stiffened up, so we said, 'We'll take you out and get you some ice on it and see how it feels tomorrow,'" manager Joe Girardi said.
Jeter himself was not available for comment after the game, but right fielder Nick Swisher doesn't need to wait until Tuesday to determine the shortstop's status for the game with Baltimore.
"I bet you $1 million he'll be in the lineup tomorrow," Swisher said to a group of reporters. "He's tough. He'll be back."
Before departing, Jeter contributed his fifth consecutive multihit game and seventh in his past eight contests. After a bit of a slump to begin this month dropped his average to a season-low .266 on May 19, Jeter is batting .429 in his past 11 games. His average climbed back over .300 on Monday.
Jeter has started 49 of the Yankees' first 50 games this season and has averaged 152 games per season over the course of his career.
Tim Britton is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.