One inning after the Yankees' third baseman launched a 3-1 pitch from the Red Sox's Josh Beckett for a solo blast in the sixth, he went deep over the left-center-field wall to trim New York's deficit to 10-7. Rodriguez's first homer struck the facing of the second deck beyond the left-field wall.
Rodriguez became the seventh and youngest member of baseball's 600-homer club on Aug. 4. Only Barry Bonds (762), Henry Aaron (755), Babe Ruth (714), Willie Mays (660) and Ken Griffey Jr. (630) have hit more home runs.
The first of Rodriguez's two homers, his 26th of the year, helped the Yankees close to within 10-3 of the Red Sox, who battered starter Andy Pettitte for seven runs in 3 1/3 innings.
A-Rod's first blast came as part of a back-to-back sequence against Beckett, with Mark Teixeira preceding it with his 31st home run of the year.
It was the eighth time the Yankees have hit back-to-back homers this season; they last did it on Aug. 30 against the A's, when Teixeira and Robinson Cano accomplished the feat.
Bryan Hoch is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.