The shortstop was hit squarely on his left leg, just above the knee, by a Scott Kazmir offering. He remained in the game and took his base, but was stranded at second when Jason Giambi struck out swinging to end the inning.
Manager Joe Torre said that Jeter "couldn't move" once he entered the dugout after the inning and that he iced the area for the remainder of the game.
"He's pretty sore, but he's going to be OK," Torre said, adding that Jeter's game-readiness would be re-evaluated on Wednesday.
Jeter was replaced by Miguel Cairo on defense to begin the second inning.
The seven-time All-Star is hitting .316 this season (25-for-79) with three doubles, a home run and six RBIs. Prior to Tuesday, he had hit in 10 straight games and 53 of his last 55. Jeter has reached base in all 18 games this year and 59 of his last 60. The most recent player to have two or fewer hitless games out of 56 was Ed Delahanty, who did it with the Phillies in 1899.
Dawn Klemish is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.