Pettitte, 34, was a winner in his last outing for the Yankees, twirling seven innings of one-run ball to topple the Rangers on May 8 at Yankee Stadium.
The start will be the eighth of the season for Pettitte, who had seen numerous opportunities for decisions evaporate thanks to late rallies against the Yankees' bullpen.
But scoring decisions against the Mariners have never been much of a problem for Pettitte. In all 17 of Pettitte's prior starts against Seattle, Pettitte has walked away with the decision, going 8-9.
The Mariners counter with left-hander Horacio Ramirez, who will be making his sixth start of the season and second against the Yankees.Pitching matchup
NYY: LHP Andy Pettitte (2-1, 2.72 ERA)
Earlier this season, Pettitte became the ninth pitcher in Yankees history to reach the 150-win plateau. He has the fourth-highest winning percentage (.642) among active left-handed pitchers. SEA: LHP Horacio Ramirez (2-2, 7.62 ERA)
Ramirez has historically done some of his best work before July. He's 23-17 with a 4.27 ERA in 56 starts before the All-Star Game. Player to watch
Keep an eye on Ichiro Suzuki, who has been among the more consistent Mariners to face Pettitte. He's batting .421 (8-for-19) with a double and five RBIs in his career against the left-hander. On the Internet
Official game notes On television
YES On radio
880 AM WCBS, 92.7 WQBU-FM (Español) Up next
Tuesday: Yankees (RHP Mike Mussina, 2-1, 4.76) at White Sox (LHP John Danks, 1-4, 4.33), 8:05 p.m. ET
Wednesday: Yankees (RHP Chien-Ming Wang, 1-3, 5.40) at White Sox (RHP Jose Contreras, 3-3, 3.79), 8:05 p.m. ET
Thursday: Yankees (RHP Matt DeSalvo, 1-0. 1.98) at White Sox (RHP Jon Garland, 2-2, 3.44), 2:05 p.m. ET
Bryan Hoch is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.