After a three-game series with the Rays, the Yankees stop in Baltimore for three contests with the Orioles before the home opener at Yankee Stadium, set for April 13 against the Los Angeles Angels of Anaheim.
New York's opening homestand, kicking off what will be the fourth season played at its new stadium, also features a four-game visit by the Minnesota Twins.
The Yankees won't have to wait long to reprise their classic matchup with the Boston Red Sox.
Their first visit to Fenway Park comes on April 20, a three-game series on a trip that also sends them to see the Texas Rangers, but the rivals won't see each other again until the Yankees are back in Boston on July 6.
The Red Sox make their first visit to Yankee Stadium on July 27, then return for another weekend on Aug. 17. The Yankees are scheduled to be in Boston for a three-game series that opens on Sept. 11.
Interleague Play kicks off with the Cincinnati Reds coming to Yankee Stadium May 18-20, again reprising the 1976 World Series, and the first round of the Subway Series has the Mets crossing into the Bronx June 8-10.
New York travels to play the Atlanta Braves at Turner Field June 11-13, rematches of the 1996 and 1999 Fall Classics, then will stop in the nation's capitol for a meeting with the Washington Nationals June 15-17.
The Braves then return the favor by coming to New York June 18-20 before the Yankees board buses and roll over to Queens, meeting the Mets at Citi Field June 22-24 to complete the intracity set.
September sets up potential for a crucial sequence, putting the Yankees on a 10-game road trip from Sept. 3 through Sept. 13 with visits to the Rays, Orioles and Red Sox before coming home for three more with Tampa Bay.
The regular season concludes with the Yankees at home, facing off for what could be an important three-game series with the Red Sox from Oct. 1-3.
It marks the first time the Yankees have been scheduled to play their 162nd game in the Bronx since 2006.