General manager Brian Cashman said that Granderson will be sent for a precautionary MRI exam on Wednesday but characterized his level of concern as "two or less" on a scale of one to 10. Cashman said that he believed Granderson first felt the injury on Tuesday.
"He reported that his elbow is a little sore," Cashman said. "We'll do a precautionary MRI to make sure it's nothing significant. We don't believe it is. Better safe than sorry."
Granderson, 31, is batting .333 (11-for-33) with one home run and four RBIs in 13 spring games. He was replaced in center by Brett Gardner, with Justin Maxwell entering New York's lineup to replace Gardner in left field.
"He went out and threw today and felt fine," Yankees manager Joe Girardi said after the game. "I'm assuming it's just precautionary. We'll know tomorrow how he feels. He felt it when he was working out a little bit, and then he went out and threw. I don't like not having him, I can tell you that."