The blast to deep left-center field in the fourth inning landed in Monument Park and scored the Yankees' lone run in a 2-1 loss.
"Alex is going to catch a lot of pretty famous people in the next upcoming years," manager Joe Girardi said. "He's an unbelievable player, he's got unbelievable power."
Next on the all-time list in Mickey Mantle, who finished with 536 homers. Rodriguez, in his 15th career year, is batting .322 with 16 home runs and 44 RBIs this season.
Foxx played for four teams --- the Philadelphia Athletics, Boston Red Sox, Chicago Cubs and Philadelphia Phillies --- from 1925-45. Foxx is the second-youngest player to reach 500 home runs at 32 years, 336 days.
The youngest? Rodriguez, eight days after his 32nd birthday.
Willie Bans is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.