Jeter hit his 203rd career home run, moving past Hall of Famer Bill Dickey and into a tie with Roger Maris for 11th place on the Yankees' all-time home run list.
The blast came in the top of the fourth inning off Blue Jays starter David Purcey. The 34-year-old shortstop lined the first pitch he saw over the right-field wall and into the New York bullpen for a two-run shot that was also his eighth home run of the season.
Jeter was asked about his milestone following the game, in which the Yankees defeated the Jays, 5-1.
"I guess I'm a home run hitter now, right?" Jeter said with a smile. "No, I don't hit too many. They're few and far between."
In addition to the home run, Jeter notched two singles and is now just two hits shy of 2,500 for his career. As if that were not enough, he is also nearing the record for the most hits all-time in Yankee Stadium.
Jeter, who has collected 1,252 hits in the Bronx, is just 17 away from Lou Gehrig's mark.
"Derek's been a spectacular player here for a long, long time," said manager Joe Girardi. "You don't reach those individual accomplishments without being consistent, staying healthy, playing every day and just being a great player.
"That's what he's done since 1996."
Jeter has also been on a tear at the plate lately, hitting .571 (16-for-27) over his last six games, including five multi-hit efforts. During that stretch, he has watched his season's batting average climb, from .284 to .298.
"At this point, it feels good to contribute," said Jeter. "All we're trying to do is win some games, so every day out, it's an important game for us, and that's the approach I take."
David Singh is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.