Granderson connected for a moonshot of a home run into the upper deck in right-center field during the fourth inning against the the Twins' Liam Hendriks. Estimated at 437 feet, it was Granderson's 40th home run of the year, making him only the fifth player in Yankees history to record 40 in back-to-back seasons.
Granderson joins Babe Ruth, Lou Gehrig, Mickey Mantle and Jason Giambi as the only other Yankees to accomplish the feat.
"Pretty neat," Granderson said. "They mentioned earlier that there's a couple guys that played for the Yankees and fall under the category, and now I'm one of them. It's neat to get mentioned with those guys -- I didn't know that.
"Especially with the number of guys that have played for the Yankees and put the pinstripes on -- at least for one sentence, I get to get mentioned with those guys. That's pretty cool."
It was the 207th home run of Granderson's career.