"It's just to try to break up some of the left-handers that we have," Girardi said. "We have a substantial amount in our lineup without the switch-hitters -- Tex [Mark Teixeira], where you could put him in between.
"I decided to take a look at this. I thought about it yesterday, doing it yesterday, but we'll go with it one more day to see how it looks. It's just to try to not make it so easy on the other team."
Brett Gardner is leading off, followed by Cano, Youkilis and lefty Travis Hafner. The order goes righty-lefty from there, with Vernon Wells, Ichiro Suzuki, Eduardo Nunez, Lyle Overbay and Francisco Cervelli.
Cano did not bat second all of last year during the regular season, though Girardi did try him there in Game 2 of the American League Championship Series against the Tigers. He has started 70 big league games batting second, most recently in 2010.
Girardi said that the idea should not be considered an effort to shake up the lineup after losing the first two games of the season.
"I think it's way too early to do that," Girardi said. "It's two games; we scored four runs last night and had some opportunities in the first day. I think it's really too early to do that, but I just don't like having three lefties in a row."
Bryan Hoch is a reporter for MLB.com. Follow him on Twitter @bryanhoch and read his MLBlog, Bombers Beat. This story was not subject to the approval of Major League Baseball or its clubs.