Cruz hurt his knee tumbling into left field during Monday's 3-0 loss to the Rangers, snaring Mitch Moreland's third-inning flare and kicking up a large divot of grass in the process. He left Rangers Ballpark on Tuesday wearing a heavy brace on the leg under his jeans.
"On the play yesterday, I dove and the spike got stuck in the grass, and my knee went [the opposite] way," Cruz said after Tuesday's 5-4 win. "It hurts really bad. I don't know what it's going to say, but I'm getting an MRI when we get back to New York. Hopefully everything's good."
Cruz finished the game but was unavailable to play on Tuesday. Girardi said that he was worried immediately about Cruz, who has played 16 games with the Yankees after starting the year with the Dodgers.
"Any time you see a player go and grab the knee, you're always really concerned," Girardi said. "And it just looked bad, the way he jammed it."
The Yankees have had 16 other players on the DL this season, serving 20 stints.
Bryan Hoch is a reporter for MLB.com. Follow him on Twitter @bryanhoch and read his MLBlog, Bombers Beat. This story was not subject to the approval of Major League Baseball or its clubs.