MLB announced on Monday that the Yankees and Red Sox will face off in the first contest of the year on Sunday night, April 4 at Fenway Park, with the 8 p.m. ET matchup televised nationally on ESPN2.
The event will mark the fifth time in the past six years that the defending World Series champions have played in the season-opening Sunday night game.
It also marks just the second time that a standalone game between the two rivals has been the first game of the season. The two clubs faced off to open the 2005 season after the Red Sox won the '04 World Series, with the Yankees winning at home, 9-2.
The 2010 season opener will be the 30th time that the Yankees and Red Sox have opened a season against each other, dating back to the first time in 1904.
New York holds an 18-10-1 record against Boston in the 29 previous openers between the clubs. The last time a Yankees-Red Sox season opener was played at Fenway Park was 1985, in a game won by Boston, 9-2.
The Yankees' home opener is set for April 13 against the Los Angeles Angels of Anaheim, in a rematch of this year's American League Championship Series.
New York's regular season will also end at Fenway Park, as the Yankees make the last of their three trips to Yawkey Way from Oct. 1-3.
Bryan Hoch is a reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.