Manager Joe Girardi wouldn't speculate on Ellsbury's availability for the rest of the weekend series, but he did sound concerned.
"His ankle is sore," Girardi said. "He hurt his ankle. I'm not sure what he's going to be for us [Saturday]. I can't tell you that he's going to play. It's frustrating because he's playing so well. We'll have to wait and see."
Ellsbury injured the ankle sliding into home plate in the top of the ninth inning. He slid into the leg of Toronto catcher Dioner Navarro and was visibly hurt before gingerly walking off the field on his own power. He was originally ruled safe before the call was overturned on a Blue Jays challenge.
The 30-year-old Ellsbury hit his 14th homer and tripled in the victory, recording his team-leading 43rd multihit game of the season.
Chris Toman is a contributor to MLB.com This story was not subject to the approval of Major League Baseball or its clubs.